Hongfang LU

Senior Research Scientist

Tel: +65 6319 4847

Email: hflu@imre.a-star.edu.sg


Senior Research Scientist, NanoBio Lab, Singapore, 2018-present

Senior Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore, 2009-2018

Postdoctoral Fellow, University of Toronto, Canada, 2003-2008 Senior Research Fellow, Johns Hopkins Singapore, 2001-2003

Lecturer, Shandong University, China, 1992-1997


Ph.D. in Chemistry, National University of Singapore, 2002

M.Sc. in Chemistry, Shandong University, China, 1992

B.Sc. in Chemistry, Shandong University, China, 1989

Publications

  1. G. Yi, S. Gao, H. Lu, W. Z. Khoo, S. Liu, S. Chng, Y. Y. Yang, J. Y. Ying, and Y. Zhang, “Surface Antimicrobial Treatment by Biocompatible, Vertically Aligned Layered Double Hydroxide Array,” Advanced Materials Interfaces 9 (9), 2101872

  2. Y. Hu, S. Gao, H. Lu, and J. Y. Ying, “Acid-Resistant and Physiological pH-Responsive DNA Hydrogel Composed of A-Motif and i-Motif toward Oral Insulin Delivery,” Journal of the American Chemical Society 2022, 144, 12, 5461–5470

  3. H.-M. Chan, N. Erathodiyil, H. Wu, H. Lu, Y. Zheng and J. Y. Ying, “Calcium Cross-Linked Zwitterionic Hydrogels as Antifouling Materials,” Materials Today Communications, 23 (2020) 100950. Impact Factor (IF) 1.859

  4. C. L. Ren, F. Chen, R. J. Ye, Y. S. Ong, H. F. Lu, S. S. Lee, J. Y. Ying, H. Q. Zeng, “Molecular Swings as Extremely Active Ion Transporters,” Angewandte Chemie International Edition, 58[24] (2019) 8034-8038

  5. Y. Yuan, H. Wu, H. F. Lu, Y. Zheng, J. Y. Ying, Y. Zhang, “ZIF Nano-Dagger Coated Gauze for Antibiotic-Free Wound Dressing,” Chemical Communications, 55 (2019) 699-702

  6. H. F. Lu, M. F. Leong, T. C. Lim, Y. P. Chua, J. K. Lim, C. Du, A. C. A. Wan, “Engineering a Functional Three-Dimensional Human Cardiac Tissue Model for Drug Toxicity Screening,” Biofabrication, 9 (2017) 025011

  7. M. F. Leong, H. F. Lu, T. C. Lim, K. Narayanan, S. Gao, L. Y. Wang, R. P. K. Toh, H. Funke, M. H. Abdul Samad, A. C. A. Wan, J. Y. Ying, “Alginate Microfiber System for Expansion and Direct Differentiation of Human Embryonic Stem Cells,” Tissue Engineering Part C Methods, 22 (2016) 884-894

  8. M. F. Leong, H. F. Lu, T. C. Lim, C. Du, N. K. L. Ma, A. C. A. Wan, “Electrospun Polystyrene Scaffolds as a Synthetic Substrate for Xeno-Free Expansion and Differentiation of Human Induced Pluripotent Stem Cells,” Acta Biomaterialia, 46 (2016) 266-277

  9. A. C. A. Wan, M. F. A. Cutiongco, B. C. U. Tai, M. F. Leong, H. F. Lu, E. K. F. Yim, “Fibers by Interfacial Polyelectrolyte Complexation - Processes, Materials and Applications,” Materials Today, 19[8] (2016) 437-450

  10. H. F. Lu, C. Chai, T. C. Lim, M. F. Leong, J. K. Lim, S. Gao, K. L. Lim, A. C. A. Wan, “A Defined Xeno-Free and Feeder-Free Culture System for the Derivation, Expansion and Direct Differentiation of Transgene-Free Patient-Specific Induced Pluripotent Stem Cells,” Biomaterials, 35[9] (2014) 2816-2826

  11. M. F. Leong, J. K. C. Toh, C. Du, K. Narayanan, H. F. Lu, T. C. Lim, A. C. A. Wan, J. Y. Ying, “Patterned Prevascularised Tissue Constructs by Assembly of Polyelectrolyte Hydrogel Fibres,” Nature Communications, 4 (2013) 2353

  12. T. C. Lim, M. F. Leong, H. Lu, C. Du, S. Gao, A. C. A. Wan, J. Y. Ying, “Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers,” Biomaterials, 34[29] (2013) 7064-7072

  13. M. Khan, K. Narayanan, H. Lu, Y. Choo, C. Du, N. Wiradharma, Y.-Y. Yang, A. C. A. Wan, “Delivery of Reprogramming Factors into Fibroblasts for Generation of Non-Genetic Induced Pluripotent Stem Cells using a Cationic Bolaamphiphile as a Non-Viral Vector,” Biomaterials, 34[21 (2013) 5336-5343

  14. H. F. Lu, S.-X. Lim, M. F. Leong, K. Narayanan, R. P. K. Toh, S. Gao, A. C. A. Wan, “Efficient Neuronal Differentiation and Maturation of Human Pluripotent Stem Cells Encapsulated in 3D Microfibrous Scaffolds,” Biomaterials, 33[36] (2012) 9179-9187

  15. H. F. Lu, K. Narayanan, S. X. Lim, S. Gao, M. F. Leong, A. C. A. Wan, “3D Microfibrous Scaffold for Long-Term Human Pluripotent Stem Cell Self-Renewal and Storage under Chemically Defined Conditions,” Biomaterials, 33[8] (2012) 2419-2430

  16. R. N. Fong, Z. Fatehi-Hassanabad, S. C. Lee, H. Lu, M. B. Wheeler, C. B. Chan, “Uncoupling Protein-2 Increases Nitric Oxide Production and TNFAIP3 Pathway Activation in Pancreatic Islets,” J. Mol. Endocrinol., 46 (2011) 193-204

  17. H. Lu, V. Koshkin, E. M. Allister, A. V. Gyulkhandanyan, M. B. Wheeler, “Molecular and Metabolic Evidence for Mitochondrial Defects Associated with Beta-Cell Dysfunction in a Mouse Model of Type 2 Diabetes,” Diabetes, 59[2] (2010) 448-59

  18. H. Lu, Y. Yang, E. M. Allister, N. Wijesekara, M. B. Wheeler, “The Identification of Potential Factors Associated With the Development of Type 2 Diabetes: A Quantitative Proteomic Approach,” Molecular & Cellular Proteomics, 7[8] (2008) 1434-1451

  19. A. V. Gyulkhandanyan, H. Lu, S. C. Lee, A. Bhattacharjee, Fox J. Manning, P. E. MacDonald, F. Dai, M.B. Wheeler, “Investigation of Transport Mechanisms and Regulation of Intracellular Zn2+ in Pancreatic α-Cells,” J. Biol. Chem. 283[15] (2008) 10184-10197

  20. H. Lu, Y. Yang, W. Wijesekara, M. B. Wheeler. “Integrated Genomic and Proteomic Analysis of the Potential Susceptibility Factors Associated with the Development of T2D in the MKR Mouse,” Diabetes, 56 (Suppl.1) (2007) A303

  21. H. F. Lu, E. D. Targonsky, M. B. Wheeler, Y. L. Cheng, “MIN6 Cell Encapsulation Using Novel Thermally-Induced Gelable Polymers,” Biotechnol Bioeng., 96[1] (2007) 146-155

  22. H. F. Lu, W. S. Lim, P. C. Zhang, S. M. Chia, H. Yu, H. Q. Mao, K. W. Leong, “Galactosylated PVDF Hollow Fiber Bioreactor for Hepatocyte Culture,” Tissue Engineering, 11[11-12] (2005) 1667-1677

  23. K. N. Chua, W. S. Lim, P. C. Zhang, H. F. Lu, J. Wen, S. Ramakrishna, K. W. Leong, H. Q. Mao, “Stable Immobilization of Rat Hepatocyte Spheroids on Galactosylated Nanofiber Scaffold,” Biomaterials, 26[15] (2005) 2537-2547

  24. H. F. Lu, K. N. Chua, P. C. Zhang, W. S. Lim, S. Ramakrishna, K. W. Leong, H. Q. Mao, “Three-Dimensional Co-Culture of Rat Hepatocyte Spheroids and NIH/3T3 Fibroblasts Enhances Hepatocyte Functional Maintenance,” Acta Biomaterialia, 1[4] (2005) 399-410

  25. H. F. Lu, W. S. Lim, J. Wang, Z. Q. Tang, P. C. Zhang, S. M. Chia, H Yu, K. W. Leong, H. Q. Mao, “Galactosylated PVDF Membrane Promotes Hepatocyte Attachment and Functional Maintenance,” Biomaterials, 24[27] (2003) 4893-4903

  26. H. F. Lu, H. S. O. Chan, S. C. Ng, “Synthesis, Characterization and Electronic & Optical Properties of Donor-Acceptor Conjugated Polymers Based on Alternating Bis(3-alkylthiophene) and Pyridine Moieties,” Macromolecules, 36[5] (2003) 1543-1552

  27. J. Wang, P. C. Zhang, H. F. Lu, N. Ma, S. Wang, H. Q. Mao, K. W. Leong, “New Polyphosphoramidate with a Spermidine Side Chain as a Gene Carrier,” Journal of Controlled Release, 83[1] (2002) 157-168

  28. K. W. Leong, H. F. Lu, C. Yin, J. C. Yang, K. N. Chua, F. Chen, S. Ramakrishna, H. Q. Mao, “Functional Fibrous Scaffolds,” Tissue Engineering, 8 (2002) 1139

  29. S. C. Ng, H. F. Lu, H. S. O. Chan, A. Fujii, T. Laga, K. Yoshino, “Novel Efficient Blue Fluorescent Polymers Comprising Alternating Phenylene Pyridine Repeat Units: Their Syntheses, Characterization, and Optical Properties,” Macromolecules, 34[20] (2001) 6895-6903

  30. T. Laga, R. Ootake, T. Fujisawa, R. Hidayat, A. Fujii, H. F. Lu, S. C. Ng, H. S. O. Chan, “Spectral Narrowing of Photoluminescence and Blue Light-Emitting Diodes of Poly(Phenylene Pyridine) Derivatives,” Synthetic Metals, 119[1-3] (2001) 601-602

  31. R. Ootake, T. Fujisawa, T. Sonoda, A. Fujii, T. Laga, H. F. Lu, S. C. Ng, H. S. O. Chan, “Optical and Electrical Properties of Poly(Phenylene Pyridine) Derivatives,” Synthetic Metals, 119[1-3] (2001) 593-594

  32. S. C. Ng, H. F. Lu, H. S. O. Chan, A. Fujii, T. Laga, K. Yoshino, “Blue Electroluminescence From a Novel Donor/Acceptor Polymer Structure,” Advanced Materials 12[15] (2000) 1122-1125

  33. A. Fujii, R. Ootake, T. Fujisawa, M. Ozaki, Y. Ohmori, T. Laga, H. F. Lu, S. C. Ng, H. S. O. Chan, “Optical Properties, Spectral Narrowing of Photoluminescence and Blue Electroluminescence of Poly(Phenylene Pyridine) Derivatives,” Applied Physics Letters, 77[5] (2000) 660-662

  34. Z. L. Liu and H. F. Lu. “Synthesis and Characterization of (7,10-Diphenylfluoran-Thene-8) Silicon Compounds,” Phosphorus Sulfur and Silicon and the Related Elements, 122 (1997) 151-154

  35. Z. L. Liu, H. F. Lu, S. X. Hao, X. Y. Wen, Z. D. Du. “Synthesis and Characterization of (3,4-Difuryl-2,5 Dimethyl)phenyl-Polyvinyl Silicon Oils,” Journal of Applied Polymer Science, 55[13] (1995) 1733-1738

  36. Z. L. Liu, H. F. Lu, Y. Z. Gao, Z. D. Du. “Synthesis and Characterization of (2,5-Dimethyl-3,4-Diphenyl)phenyl Silicon-Compounds,” Phosphorus Sulfur and Silicon and the Related Elements, 86[1-4] (1994) 193-195

Patents